The club was formed in 1878 in the Rutherglen district of Glasgow. They joined Scottish Division One in 1897-92 when the league was increased to twelve clubs.

In 1893-94 Clyde only finished third in Division Two but were elected to the top division nonetheless.

Clyde's highest league position of 3rd has been achieved on three occasions in 1908-09, 1911-12 and 1966-67. They have won the Division Two title three times since the Premier League came into being, in 1977-78,1981-82 and 1992-93.